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Prostaglandin E(2) stimulates expression of osmoprotective genes in MDCK cells and promotes survival under hypertonic conditions

The cells of the renal medulla produce large amounts of prostaglandin E(2) (PGE(2)) via cyclooxygenases (COX)-1 and -2. PGE(2) is well known to play a critical role in salt and water balance and maintenance of medullary blood flow. Since renal medullary PGE(2) production increases in antidiuresis, a...

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Autors principals: Neuhofer, Wolfgang, Steinert, Daniela, Fraek, Maria-Luisa, Beck, Franz-X
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277232/
https://ncbi.nlm.nih.gov/pubmed/17556390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.135178
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