Focal adhesion kinase regulates the activity of the osmosensitive transcription factor TonEBP/NFAT5 under hypertonic conditions

TonEBP/NFAT5 is a major regulator of the urinary concentrating process and is essential for the osmoadaptation of renal medullary cells. Focal adhesion kinase (FAK) is a mechanosensitive non-receptor protein tyrosine kinase expressed abundantly in the renal medulla. Since osmotic stress causes cell...

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Detalhes bibliográficos
Main Authors: Neuhofer, Wolfgang, Küper, Christoph, Lichtnekert, Julia, Holzapfel, Konstantin, Rupanagudi, Khader V., Fraek, Maria-Luisa, Bartels, Helmut, Beck, Franz-Xaver
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983490/
https://ncbi.nlm.nih.gov/pubmed/24772088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00123
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