Restriction of placental growth in sheep impairs insulin secretion but not sensitivity before birth

Restricted growth before birth is associated with impaired insulin secretion but with initially enhanced insulin sensitivity in early postnatal life, which then progresses to insulin resistance and impaired glucose homeostasis by adulthood. This suggests that prenatal restraint impairs insulin secre...

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Autores principales: Owens, Julie A, Gatford, Kathryn L, De Blasio, Miles J, Edwards, Lisa J, McMillen, I Caroline, Fowden, Abigail L
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2007
Materias:
Renal And Endocrine
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276990/
https://ncbi.nlm.nih.gov/pubmed/17761772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.142141
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