Degradation of MEPE, DMP1, and Release of SIBLING ASARM-Peptides (Minhibins): ASARM-Peptide(s) Are Directly Responsible for Defective Mineralization in HYP

Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and DMP1 (dentin matrix protein 1) result in X-linked hypophosphatemic rickets (HYP) and autosomal-recessive hypophosphatemic-rickets (ARHR), respectively. Specific binding of PHEX to matrix extracell...

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Autores principales: Martin, Aline, David, Valentin, Laurence, Jennifer S., Schwarz, Patricia M., Lafer, Eileen M., Hedge, Anne-Marie, Rowe, Peter S. N.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Endocrine Society 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276704/
https://ncbi.nlm.nih.gov/pubmed/18162525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1205
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