Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE–ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)

Matrix Extracellular Phospho-glycoprotEin (MEPE) and proteases are elevated and PHEX is defective in HYP. PHEX prevents proteolysis of MEPE and release of a protease-resistant MEPE–ASARM peptide, an inhibitor of mineralization (minhibin). Thus, in HYP, mutated PHEX may contribute to increased ASARM...

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Detalhes bibliográficos
Main Authors: Rowe, Peter S.N., Garrett, Ian R., Schwarz, Patricia M., Carnes, David L., Lafer, Eileen M., Mundy, Gregory R., Gutierrez, Gloria E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361744/
https://ncbi.nlm.nih.gov/pubmed/15664000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2004.09.015
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