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Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation
The selective and potent inhibition of mitochondrial translation in Saccharomyces cerevisiae by pentamidine suggests a novel antimicrobial action for this drug. Electrophoresis mobility shift assay, T1 ribonuclease footprinting, hydroxyl radical footprinting and isothermal titration calorimetry coll...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275129/ https://ncbi.nlm.nih.gov/pubmed/18263620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1180 |
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