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Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation

The selective and potent inhibition of mitochondrial translation in Saccharomyces cerevisiae by pentamidine suggests a novel antimicrobial action for this drug. Electrophoresis mobility shift assay, T1 ribonuclease footprinting, hydroxyl radical footprinting and isothermal titration calorimetry coll...

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Sonraí Bibleagrafaíochta
Main Authors: Sun, Tao, Zhang, Yi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2008
Ábhair:
RNA
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275129/
https://ncbi.nlm.nih.gov/pubmed/18263620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1180
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