RNA Binding Targets Aminoacyl-tRNA Synthetases to Translating Ribosomes

Here, we examine tRNA-aminoacyl synthetase (ARS) localization in protein synthesis. Proteomics reveals that ten of the twenty cytosolic ARSs associate with ribosomes in sucrose gradients: phenylalanyl-RS (FRS), and the 9 ARSs that form the multi-ARS complex (MSC). Using the ribopuromycylation method...

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Autores principales: David, Alexandre, Netzer, Nir, Strader, Michael Brad, Das, Suman R., Chen, Cai Yun, Gibbs, James, Pierre, Philippe, Bennink, Jack R., Yewdell, Jonathan W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Protein Synthesis and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121505/
https://ncbi.nlm.nih.gov/pubmed/21460219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.209452
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