The Lupus-related Lmb3 Locus Contains a Disease-suppressing Coronin-1A Gene Mutation

Here we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene. This mutation is associated with developmental and functional alterations in T cells, reduced T-dependent humoral responses, and no detectable intrinsic B cell defects. B...

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Main Authors: Haraldsson, M. Katarina, Louis-Dit-Sully, Christine A., Lawson, Brian R., Sternik, Gabriel, Santiago-Raber, Marie-Laure, Gascoigne, Nicholas R. J., Theofilopoulos, Argyrios N., Kono, Dwight H.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2274909/
https://ncbi.nlm.nih.gov/pubmed/18199416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.11.023
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