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Novel, Orally Effective Cyanide Antidotes

A series of prodrugs of 3-mercaptopyruvate (3-MP), the substrate for the enzyme 3-mercaptopyruvate/cyanide sulfurtransferase (3-MPST) that converts cyanide to the nontoxic thiocyanate, which are highly effective cyanide antidotes, have been developed. These prodrugs of 3-MP are unique in being not o...

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Detalhes bibliográficos
Main Authors: Nagasawa, Herbert T., Goon, David J. W., Crankshaw, Daune L., Vince, Robert, Patterson, Steven E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2274902/
https://ncbi.nlm.nih.gov/pubmed/18038966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm7011497
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