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A Novel Paradigm for Assessing Efficacies of Potential Antidotes against Neurotoxins in Mice
Historically, antidotal potencies of cyanide antagonists were measured as increases in the experimental LD(50) for cyanide elicited by the antidotes. This required the use of high doses of cyanide following pretreatment with the putative antidote. Since IACUC guidelines at our institutions strongly...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2171362/ https://ncbi.nlm.nih.gov/pubmed/18024011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2007.10.001 |
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