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A Novel Paradigm for Assessing Efficacies of Potential Antidotes against Neurotoxins in Mice

Historically, antidotal potencies of cyanide antagonists were measured as increases in the experimental LD(50) for cyanide elicited by the antidotes. This required the use of high doses of cyanide following pretreatment with the putative antidote. Since IACUC guidelines at our institutions strongly...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Crankshaw, Daune L., Goon, David J.W., Briggs, Jacquie E., DeLong, David, Kuskowski, Michael, Patterson, Steven E., Nagasawa, Herbert T.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2007
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171362/
https://ncbi.nlm.nih.gov/pubmed/18024011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2007.10.001
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