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Transformation efficiency of Q61 Ras mutants linked to structural features of the switch regions
Transformation efficiencies of Ras mutants at residue 61 range over three orders of magnitude, but the in vitro GTPase activity decreases 10-fold for all mutants. We show that Raf impairs the GTPase activity of RasQ61L, suggesting that the Ras/Raf complex differentially modulates transformation. Our...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2273997/ https://ncbi.nlm.nih.gov/pubmed/18073111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.10.011 |
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