Endothelin-1 and photoreleased diacylglycerol increase L-type Ca(2+) current by activation of protein kinase C in rat ventricular myocytes

1. The amphotericin B-perforated whole-cell patch clamp technique was used to determine the modulation of L-type Ca(2+) channels by protein kinase C (PKC)-mediated pathways in adult rat ventricular myocytes. 2. Application of 10 nM endothelin-1 (ET-1) increased peak Ca(2+) current (I(Ca)) by 28·2 ±...

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Detalhes bibliográficos
Main Authors: He, Jia-Qiang, Pi, YeQing, Walker, Jeffery W, Kamp, Timothy J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269902/
https://ncbi.nlm.nih.gov/pubmed/10790160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2000.00807.x
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