The 4′lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT(3A) receptors

1. The 5-HT(3) receptor is a transmitter-gated ion channel of the Cys-loop superfamily. Uniquely, 5-HT(3) receptor subunits (5-HT(3A) and 5-HT(3B)) possess a positively charged lysine residue within the putative channel lining M2 domain (4′ position). Using whole cell recording techniques, we examin...

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Main Authors: Gunthorpe, Martin J, Peters, John A, Gill, Catherine H, Lambert, Jeremy J, Lummis, Sarah C R
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 2000
主題:
Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269757/
https://ncbi.nlm.nih.gov/pubmed/10639097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2000.00187.x
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