Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma

The heparan sulfate (HS) proteoglycan, syndecan-1, plays a major role in multiple myeloma (MM) by concentrating heparin-binding growth factors on the surface of MM cells (MMC). Using Affymetrix microarrays and real-time RT-PCR, we show that the gene encoding heparanase (HPSE), an enzyme that cleaves...

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Hauptverfasser: Mahtouk, Karène, Hose, Dirk, Raynaud, Pierre, Hundemer, Michael, Jourdan, Michel, Jourdan, Eric, Pantesco, Véronique, Baudard, Marion, De Vos, John, Larroque, Marion, Moehler, Thomas, Rossi, Jean-François, Reme, Thierry, Goldschmidt, Hartmut, Klein, Bernard
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268882/
https://ncbi.nlm.nih.gov/pubmed/17339423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-08-043232
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