The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature

BAFF and APRIL have been shown to promote multiple myeloma (MM) cell growth. We show that the main site of production for BAFF and APRIL is the bone marrow (BM) environment, mainly by monocytes and neutrophils. In addition, osteoclasts produce very high levels of APRIL, unlike BM stromal cells. Myel...

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Main Authors: Moreaux, Jérôme, Cremer, Friedrich W., Reme, Thierry, Raab, Marc, Mahtouk, Karene, Kaukel, Philine, Pantesco, Veronique, De Vos, John, Jourdan, Eric, Jauch, Anna, Legouffe, Eric, Moos, Marion, Fiol, Genevieve, Goldschmidt, Hartmut, Rossi, Jean François, Hose, Dirk, Klein, Bernard
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408610/
https://ncbi.nlm.nih.gov/pubmed/15827134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-11-4512
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