Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma

The epidermal growth factor (EGF)/EGF-receptor (ErbB1-4) family is involved in the biology of multiple myeloma (MM). In particular, ErbB-specific inhibitors induce strong apoptosis of myeloma cells (MMC) in vitro. To delineate the contribution of the 10 EGF-family ligands to the pathogenesis of MM,...

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Main Authors: Mahtouk, Karène, Cremer, Friedrich W., Rème, Thierry, Jourdan, Michel, Baudard, Marion, Moreaux, Jérome, Requirand, Guilhem, Fiol, Geneviève, De Vos, John, Moos, Marion, Quittet, Philippe, Goldschmidt, Hartmut, Rossi, Jean-François, Hose, Dirk, Klein, Bernard
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2006
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396200/
https://ncbi.nlm.nih.gov/pubmed/16732320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1209699
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