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Opening and closing of the periplasmic gate in lactose permease

X-ray crystal structures of lactose permease (LacY) reveal pseudosymmetrically arranged N- and C-terminal six-transmembrane helix bundles surrounding a deep internal cavity open on the cytoplasmic side and completely closed on the periplasmic side. The residues essential for sugar recognition and H(...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Yonggang, Guan, Lan, Freites, J. Alfredo, Kaback, H. Ronald
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268789/
https://ncbi.nlm.nih.gov/pubmed/18319336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800825105
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