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Binding affinity of lactose permease is not altered by the H(+) electrochemical gradient

The x-ray structure of lactose permease of Escherichia coli (LacY) exhibits a single sugar-binding site at the apex of a hydrophilic cavity open to the cytoplasm, and it has been postulated that the binding site has alternating access to either side of the membrane during turnover. Here, the affinit...

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Detalhes bibliográficos
Main Authors: Guan, Lan, Kaback, H. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC514448/
https://ncbi.nlm.nih.gov/pubmed/15304639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404936101
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