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E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models
The majority of clinical trials evaluating replication-selective oncolytic adenoviruses utilized mutants with immunomodulatory E3B genes deleted, likely contributing to the attenuated efficacy. We investigated whether an intact immune response could contribute to the observed improved efficacy in re...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268748/ https://ncbi.nlm.nih.gov/pubmed/18034197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.cgt.7701099 |
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