Human HLA-DR Transgenes Protect Mice from Fatal Virus-Induced Encephalomyelitis and Chronic Demyelination

We evaluated the participatory role of human HLA-DR molecules in control of virus from the central nervous system and in the development of subsequent spinal cord demyelination. The experiments utilized intracranial infection with Theiler's murine encephalomyelitis virus (TMEV), a picornavirus...

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Библиографические подробности
Главные авторы: Rodriguez, Moses, Zoecklein, Laurie, Kerkvliet, Jason G., Pavelko, Kevin D., Papke, Louisa, Howe, Charles L., Pease, Larry R., David, Chella
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2008
Предметы:
Pathogenesis and Immunity
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268466/
https://ncbi.nlm.nih.gov/pubmed/18234804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02243-07
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