Gamma Interferon Is Critical for Neuronal Viral Clearance and Protection in a Susceptible Mouse Strain following Early Intracranial Theiler's Murine Encephalomyelitis Virus Infection

We evaluated the role of gamma interferon (IFN-γ) in protecting neurons from virus-induced injury following central nervous system infection. IFN-γ(−/−) and IFN-γ(+/+) mice of the resistant major histocompatibility complex (MHC) H-2(b) haplotype and intracerebrally infected with Theiler's murin...

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Bibliographic Details
Published in:J Virol
Main Authors: Rodriguez, Moses, Zoecklein, Laurie J., Howe, Charles L., Pavelko, Kevin D., Gamez, Jeff D., Nakane, Shunya, Papke, Louisa M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2003
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC254254/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14581562/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.22.12252-12265.2003
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