T-Cell Receptor-Induced NF-κB Activation Is Negatively Regulated by E3 Ubiquitin Ligase Cbl-b

It has previously been shown that E3 ubiquitin ligase Casitas B-lineage lymphoma-b (Cbl-b) negatively regulates T-cell activation, but the molecular mechanism(s) underlying this inhibition is not completely defined. In this study, we report that the loss of Cbl-b selectively results in aberrant acti...

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Main Authors: Qiao, Guilin, Li, Zhenping, Molinero, Luciana, Alegre, Maria-Luisa, Ying, Haiyan, Sun, Zuoming, Penninger, Josef M., Zhang, Jian
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2008
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268433/
https://ncbi.nlm.nih.gov/pubmed/18227156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01505-07
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