The Absence of Ser389 Phosphorylation in p53 Affects the Basal Gene Expression Level of Many p53-Dependent Genes and Alters the Biphasic Response to UV Exposure in Mouse Embryonic Fibroblasts

Phosphorylation is important in p53-mediated DNA damage responses. After UV irradiation, p53 is phosphorylated specifically at murine residue Ser389. Phosphorylation mutant p53.S389A cells and mice show reduced apoptosis and compromised tumor suppression after UV irradiation. We investigated the und...

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Main Authors: Bruins, Wendy, Bruning, Oskar, Jonker, Martijs J., Zwart, Edwin, van der Hoeven, Tessa V., Pennings, Jeroen L. A., Rauwerda, Han, de Vries, Annemieke, Breit, Timo M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268391/
https://ncbi.nlm.nih.gov/pubmed/18195040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01610-07
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