Serious complications in gene-expression studies with stress perturbation: An example of UV-exposed p53-mutant mouse embryonic fibroblasts

Reanalysis of our UV study of p53-mutant mouse embryonic fibroblasts revealed an intriguing orchestration of massive transcriptome responses. However, close scrutiny of the data uncovered an affected mRNA/rRNA ratio, effectively inhibiting valid data analysis. UV-dose range-finding showed low-dose U...

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Main Authors: Bruning, Oskar, Yuan, Xiaolian, Rodenburg, Wendy, Bruins, Wendy, van Oostrom, Conny T, Rauwerda, Han, Wittink, Floyd RA, Jonker, Martijs J, de Vries, Annemieke, Breit, Timo M
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2010
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023578/
https://ncbi.nlm.nih.gov/pubmed/21326892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.1.3.13487
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