Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110α and β by protease-activated receptor 2 and β-arrestins

PAR-2 (protease-activated receptor 2) is a GPCR (G-protein-coupled receptor) that can elicit both G-protein-dependent and -independent signals. We have shown previously that PAR-2 simultaneously promotes Gαq/Ca(2+)-dependent activation and β-arrestin-1-dependent inhibition of class IA PI3K (phosphoi...

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Autores principales: Wang, Ping, Kumar, Puneet, Wang, Chang, DeFea, Kathryn A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2007
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267348/
https://ncbi.nlm.nih.gov/pubmed/17680774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070483
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