Extracellular Transglutaminase 2 Is Catalytically Inactive, but Is Transiently Activated upon Tissue Injury

Transglutaminase 2 (TG2) is a multifunctional mammalian protein with transamidase and signaling properties. Using selective TG2 inhibitors and tagged nucleophilic amine substrates, we show that the majority of extracellular TG2 is inactive under normal physiological conditions in cell culture and in...

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Main Authors: Siegel, Matthew, Strnad, Pavel, Watts, R. Edward, Choi, Kihang, Jabri, Bana, Omary, M. Bishr, Khosla, Chaitan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267210/
https://ncbi.nlm.nih.gov/pubmed/18365016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001861
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