Transglutaminase 2 Undergoes a Large Conformational Change upon Activation

Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathogenesis of celiac sprue. Although vertebrate transglutaminases have been...

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Main Authors: Pinkas, Daniel M, Strop, Pavel, Brunger, Axel T, Khosla, Chaitan
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2140088/
https://ncbi.nlm.nih.gov/pubmed/18092889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050327
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2140088/
https://ncbi.nlm.nih.gov/pubmed/18092889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050327