Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

Through the adoptive transfer of lymphocytes after host immunodepletion, it is possible to mediate objective cancer regression in human patients with metastatic melanoma. However, the generation of tumor-specific T cells in this mode of immunotherapy is often limiting. Here we report the ability to...

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Main Authors: Morgan, Richard A., Dudley, Mark E., Wunderlich, John R., Hughes, Marybeth S., Yang, James C., Sherry, Richard M., Royal, Richard E., Topalian, Suzanne L., Kammula, Udai S., Restifo, Nicholas P., Zheng, Zhili, Nahvi, Azam, de Vries, Christiaan R., Rogers-Freezer, Linda J., Mavroukakis, Sharon A., Rosenberg, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267026/
https://ncbi.nlm.nih.gov/pubmed/16946036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1129003
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