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The Tarantula Toxin Psalmotoxin 1 Inhibits Acid-sensing Ion Channel (ASIC) 1a by Increasing Its Apparent H(+) Affinity

Acid-sensing ion channels (ASICs) are ion channels activated by extracellular protons. They are involved in higher brain functions and perception of pain, taste, and mechanical stimuli. Homomeric ASIC1a is potently inhibited by the tarantula toxin psalmotoxin 1. The mechanism of this inhibition is u...

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Bibliografiske detaljer
Main Authors: Chen, Xuanmao, Kalbacher, Hubert, Gründer, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266618/
https://ncbi.nlm.nih.gov/pubmed/15955877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200509303
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