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Identification of the Ca(2+) Blocking Site of Acid-sensing Ion Channel (ASIC) 1: Implications for Channel Gating

Acid-sensing ion channels ASIC1a and ASIC1b are ligand-gated ion channels that are activated by H(+) in the physiological range of pH. The apparent affinity for H(+) of ASIC1a and 1b is modulated by extracellular Ca(2+) through a competition between Ca(2+) and H(+). Here we show that, in addition to...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Paukert, Martin, Babini, Elena, Pusch, Michael, Gründer, Stefan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233906/
https://ncbi.nlm.nih.gov/pubmed/15452199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308973
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