Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island of hMLH1 is found in the majority of sporadic primary colorectal cancers with MSI, and that this methylation was of...

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Main Authors: Herman, James G., Umar, Asad, Polyak, Kornelia, Graff, Jeremy R., Ahuja, Nita, Issa, Jean-Pierre J., Markowitz, Sanford, Willson, James K. V., Hamilton, Stanley R., Kinzler, Kenneth W., Kane, Michael F., Kolodner, Richard D., Vogelstein, Bert, Kunkel, Thomas A., Baylin, Stephen B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 1998
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC22665/
https://ncbi.nlm.nih.gov/pubmed/9618505
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