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hMLH1 Promoter Hypermethylation Is an Early Event in Human Endometrial Tumorigenesis

It has recently been suggested that silencing of the hMLH1 gene by promoter hypermethylation is the mechanism underlying the presence of the microsatellite instability (MSI) phenotype in sporadic colon and endometrial carcinomas. To determine whether hMLH1 promoter hypermethylation is a relatively e...

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Detalhes bibliográficos
Main Authors: Esteller, Manel, Catasus, Lluis, Matias-Guiu, Xavier, Mutter, George L., Prat, Jaime, Baylin, Steve B., Herman, James G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866976/
https://ncbi.nlm.nih.gov/pubmed/10550333
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