Mutually Exclusive Promoter Hypermethylation Patterns of hMLH1 and O(6)-Methylguanine DNA Methyltransferase in Colorectal Cancer

Hypermethylation of CpG islands in gene promoter regions is an important mechanism of gene inactivation in cancer. Many cellular pathways, including DNA repair, are inactivated by this type of epigenetic lesion, resulting in proposed mutator phenotypes. Promoter hypermethylation of hMLH1 has been im...

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Detalhes bibliográficos
Main Authors: Fox, Edward J., Leahy, Dermot T., Geraghty, Robert, Mulcahy, Hugh E., Fennelly, David, Hyland, John M., O’Donoghue, Diarmuid P., Sheahan, Kieran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867561/
https://ncbi.nlm.nih.gov/pubmed/16436636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2006.050084
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