Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island of hMLH1 is found in the majority of sporadic primary colorectal cancers with MSI, and that this methylation was of...

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Detalhes bibliográficos
Main Authors: Herman, James G., Umar, Asad, Polyak, Kornelia, Graff, Jeremy R., Ahuja, Nita, Issa, Jean-Pierre J., Markowitz, Sanford, Willson, James K. V., Hamilton, Stanley R., Kinzler, Kenneth W., Kane, Michael F., Kolodner, Richard D., Vogelstein, Bert, Kunkel, Thomas A., Baylin, Stephen B.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22665/
https://ncbi.nlm.nih.gov/pubmed/9618505
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