Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: The predominant role of hMLH1

Fifteen to twenty-five percent of sporadic colorectal carcinomas are replication error (RER) positive. Because the frequency of mutations in the mismatch repair genes (hMLH1 and hMSH2) is low in these tumors, we have investigated the role of mutational inactivation, methylation of the promoter regio...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wheeler, J. M. D., Beck, N. E., Kim, H. C., Tomlinson, I. P. M., Mortensen, N. J. McC., Bodmer, W. F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17882/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468602/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10296
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