Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3

Auranofin (AF) is a sulphur-containing gold compound. Because of its anti-inflammatory and immunosuppressive activities, AF has been widely used for the therapeutic treatment of rheumatoid arthritis. However, little is known about its mechanism of action. To elucidate the molecular mechanism underly...

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Detalhes bibliográficos
Main Authors: Kim, Nam-Hoon, Lee, Mun-Yong, Park, Seon-Joo, Choi, Jeong-Sun, Oh, Mi-Kyung, Kim, In-Sook
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266044/
https://ncbi.nlm.nih.gov/pubmed/17645497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2007.02679.x
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