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A hexanucleotide selected for increased cellular uptake in cis contains a highly active CpG-motif in human B cells and primary peripheral blood mononuclear cells

The relationship between immunostimulation of human B cells by cytosine–phosphate–guanosine (CpG) -containing oligonucleotides and their physical cellular uptake is of mechanistic interest and a prerequisite for rational improvements of the therapeutic potential of CpG-harbouring oligonucleotides. H...

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Detalhes bibliográficos
Main Authors: Mende, Miriam, Hopert, Anne, Wünsche, Winfried, Overhoff, Marita, Detzer, Anke, Börngen, Kirsten, Schlenke, Peter, Kirchner, Holger, Sczakiel, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265851/
https://ncbi.nlm.nih.gov/pubmed/17137465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2006.02497.x
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