Cdk1 and Cdk2 activity levels determine the efficiency of replication origin firing in Xenopus

In this paper, we describe how, in a model embryonic system, cyclin-dependent kinase (Cdk) activity controls the efficiency of DNA replication by determining the frequency of origin activation. Using independent approaches of protein depletion and selective chemical inhibition of a single Cdk, we fi...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Krasinska, Liliana, Besnard, Emilie, Cot, Emilie, Dohet, Christiane, Méchali, Marcel, Lemaitre, Jean-Marc, Fisher, Daniel
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2008
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265753/
https://ncbi.nlm.nih.gov/pubmed/18256689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.16
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