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Replication initiation complex formation in the absence of nuclear function in Xenopus
In this article, we study how intercalation-induced changes in chromatin and DNA topology affect chromosomal DNA replication using Xenopus egg extracts. Unexpectedly, intercalation by ethidium or doxorubicin prevents formation of a functional nucleus: although nucleosome formation occurs, DNA decond...
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Main Authors: | , |
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Formato: | Artigo |
Idioma: | Inglês |
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Oxford University Press
2009
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673427/ https://ncbi.nlm.nih.gov/pubmed/19237397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp081 |
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