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Cdk1 and Cdk2 activity levels determine the efficiency of replication origin firing in Xenopus
In this paper, we describe how, in a model embryonic system, cyclin-dependent kinase (Cdk) activity controls the efficiency of DNA replication by determining the frequency of origin activation. Using independent approaches of protein depletion and selective chemical inhibition of a single Cdk, we fi...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2265753/ https://ncbi.nlm.nih.gov/pubmed/18256689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.16 |
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