A novel switch region regulates H-ras membrane orientation and signal output

The plasma membrane nanoscale distribution of H-ras is regulated by guanine nucleotide binding. To explore the structural basis of H-ras membrane organization, we combined molecular dynamic simulations and medium-throughput FRET measurements on live cells. We extracted a set of FRET values, termed a...

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Bibliografiske detaljer
Main Authors: Abankwa, Daniel, Hanzal-Bayer, Michael, Ariotti, Nicolas, Plowman, Sarah J, Gorfe, Alemayehu A, Parton, Robert G, McCammon, J Andrew, Hancock, John F
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265749/
https://ncbi.nlm.nih.gov/pubmed/18273062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.10
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