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Ras membrane orientation and nanodomain localization generate isoform diversity

The structural elements encoding functional diversity among Ras GTPases are poorly defined. The orientation of the G domain of H-ras with respect to the plane of the plasma membrane is recognized by the Ras binding domain of C-Raf, coupling orientation to MAPK activation. We now show that two other...

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Detalles Bibliográficos
Main Authors: Abankwa, Daniel, Gorfe, Alemayehu A., Inder, Kerry, Hancock, John F.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824305/
https://ncbi.nlm.nih.gov/pubmed/20080631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903907107
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