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A novel switch region regulates H-ras membrane orientation and signal output
The plasma membrane nanoscale distribution of H-ras is regulated by guanine nucleotide binding. To explore the structural basis of H-ras membrane organization, we combined molecular dynamic simulations and medium-throughput FRET measurements on live cells. We extracted a set of FRET values, termed a...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2265749/ https://ncbi.nlm.nih.gov/pubmed/18273062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.10 |
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