Important role of matrix metalloproteinase 9 in epileptogenesis

Temporal lobe epilepsy (TLE) is a devastating disease in which aberrant synaptic plasticity plays a major role. We identify matrix metalloproteinase (MMP) 9 as a novel synaptic enzyme and a key pathogenic factor in two animal models of TLE: kainate-evoked epilepsy and pentylenetetrazole (PTZ) kindli...

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Autors principals: Wilczynski, Grzegorz M., Konopacki, Filip A., Wilczek, Ewa, Lasiecka, Zofia, Gorlewicz, Adam, Michaluk, Piotr, Wawrzyniak, Marcin, Malinowska, Monika, Okulski, Pawel, Kolodziej, Lukasz R., Konopka, Witold, Duniec, Kamila, Mioduszewska, Barbara, Nikolaev, Evgeni, Walczak, Agnieszka, Owczarek, Dorota, Gorecki, Dariusz C., Zuschratter, Werner, Ottersen, Ole Petter, Kaczmarek, Leszek
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2008
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Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265409/
https://ncbi.nlm.nih.gov/pubmed/18332222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200708213
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