Important role of matrix metalloproteinase 9 in epileptogenesis

Temporal lobe epilepsy (TLE) is a devastating disease in which aberrant synaptic plasticity plays a major role. We identify matrix metalloproteinase (MMP) 9 as a novel synaptic enzyme and a key pathogenic factor in two animal models of TLE: kainate-evoked epilepsy and pentylenetetrazole (PTZ) kindli...

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Hauptverfasser: Wilczynski, Grzegorz M., Konopacki, Filip A., Wilczek, Ewa, Lasiecka, Zofia, Gorlewicz, Adam, Michaluk, Piotr, Wawrzyniak, Marcin, Malinowska, Monika, Okulski, Pawel, Kolodziej, Lukasz R., Konopka, Witold, Duniec, Kamila, Mioduszewska, Barbara, Nikolaev, Evgeni, Walczak, Agnieszka, Owczarek, Dorota, Gorecki, Dariusz C., Zuschratter, Werner, Ottersen, Ole Petter, Kaczmarek, Leszek
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2008
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265409/
https://ncbi.nlm.nih.gov/pubmed/18332222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200708213
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