Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

Although the majority of colorectal cancers exhibit chromosome instability (CIN), only a few genes that might cause this phenotype have been identified and no general mechanism underlying their function has emerged. To systematically identify somatic mutations in potential CIN genes in colorectal ca...

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Autors principals: Barber, Thomas D., McManus, Kirk, Yuen, Karen W. Y., Reis, Marcelo, Parmigiani, Giovanni, Shen, Dong, Barrett, Irene, Nouhi, Yasaman, Spencer, Forrest, Markowitz, Sanford, Velculescu, Victor E., Kinzler, Kenneth W., Vogelstein, Bert, Lengauer, Christoph, Hieter, Philip
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265152/
https://ncbi.nlm.nih.gov/pubmed/18299561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712384105
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