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Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing
Mutations that cause chromosome instability (CIN) in cancer cells produce “sublethal” deficiencies in an essential process (chromosome segregation) and, therefore, may represent a major untapped resource that could be exploited for therapeutic benefit in the treatment of cancer. If second-site unlin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651317/ https://ncbi.nlm.nih.gov/pubmed/19218431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813414106 |
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