Akt and CHIP coregulate tau degradation through coordinated interactions

A hallmark of the pathology of Alzheimer's disease is the accumulation of the microtubule-associated protein tau into fibrillar aggregates. Recent studies suggest that they accumulate because cytosolic chaperones fail to clear abnormally phosphorylated tau, preserving a pool of toxic tau interm...

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Detalhes bibliográficos
Main Authors: Dickey, Chad A., Koren, John, Zhang, Yong-Jie, Xu, Ya-fei, Jinwal, Umesh K., Birnbaum, Morris J., Monks, Bobby, Sun, Mei, Cheng, Jin Q., Patterson, Cam, Bailey, Rachel M., Dunmore, Judith, Soresh, Sareh, Leon, Carlos, Morgan, Dave, Petrucelli, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265134/
https://ncbi.nlm.nih.gov/pubmed/18292230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709180105
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