Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species

The host range of retroviruses is influenced by antiviral proteins such as TRIM5, a restriction factor that recognizes and inactivates incoming retroviral capsids. Remarkably, in Owl monkeys (omk), a cyclophilin A (CypA) cDNA has been transposed into the TRIM5 locus, resulting in the expression of a...

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Bibliographic Details
Main Authors: Virgen, Cesar A., Kratovac, Zerina, Bieniasz, Paul D., Hatziioannou, Theodora
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265128/
https://ncbi.nlm.nih.gov/pubmed/18287034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709258105
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